Anti-C3c Antibody [013E-498.2.3 (10-02A)] (A278893)

Anti-C3c Antibody [013E-498.2.3 (10-02A)]

Mouse monoclonal [013E-498.2.3 (10-02A)] antibody to C3c.

This antibody recognises the ~135 kDa complement component 3c present in serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.

Flow Cytometry, ELISA, IHC-Fr, WB

Human

Human C3 from normal serum, highly purified by chromatography.

Mouse

Monoclonal

013E-498.2.3 (10-02A)

IgG1

Unconjugated

Protein A affinity chromatography of ascites.

Liquid

Supplied in Borate Buffered Saline with 0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti human C3c, clone 013E-498.2.3 (10-02A), recognizes the ~135 kDa complement component 3c present in serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.

acylation-stimulating protein cleavage product, AHUS5, ARMD9, ASP, C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3a, C3a anaphylatoxin, C3b, CO3_HUMAN, Complement C3, Complement C3c, Complement C3c alpha' chain fragment 2, Complement component 3, Complement component C3, Complement component C3a, Complement component C3b, Complement factor 3, CPAMD1, Prepro C3