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Anti-Calcium Sensing Receptor Antibody (Biotin)

Rabbit polyclonal antibody to Calcium Sensing Receptor (Biotin) from FabGennix (CASR-BIOTIN).
Name: Anti-Calcium Sensing Receptor Antibody (Biotin)
Description: Rabbit polyclonal antibody to Calcium Sensing Receptor (Biotin)
Applications: ELISA, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.7 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage
Function: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Tissue Specificity: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
Involvement in Disease: Hypocalciuric hypercalcemia, familial 1: A form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults.

Hyperparathyroidism, neonatal severe: A disorder characterized by severe hypercalcemia, bone demineralization, and failure to thrive usually manifesting in the first 6 months of life. If untreated, NSHPT can be a devastating neurodevelopmental disorder, which in some cases is lethal without parathyroidectomy.

Hypocalcemia, autosomal dominant 1: A disorder of mineral homeostasis characterized by blood calcium levels below normal, and low or normal serum parathyroid hormone concentrations. Disease manifestations include mild or asymptomatic hypocalcemia, paresthesias, carpopedal spasm, seizures, hypercalciuria with nephrocalcinosis or kidney stones, and ectopic and basal ganglia calcifications. Few patients manifest hypocalcemia and features of Bartter syndrome, including hypomagnesemia, hypokalemia, metabolic alkalosis, hyperreninemia, and hyperaldosteronemia.

Epilepsy, idiopathic generalized 8: A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Seizure types are variable, but include myoclonic seizures, absence seizures, febrile seizures, complex partial seizures, and generalized tonic-clonic seizures.
Sequence Similarities: Belongs to the G-protein coupled receptor 3 family.
Post-Translational Modification: N-glycosylated.
Cellular Location: Cell membrane.
UniProt: P41180
Synonyms: Ca sensing receptor Antibody
Ca2+ sensing receptor Antibody
Ca2+ sensing receptor 1 Antibody
CAR Antibody
CaSR Antibody
EIG8 Antibody
Extracellular calcium sensing receptor Antibody
Extracellular calcium sensing receptor [Precursor] Antibody
Extracellular calcium-sensing receptor Antibody
FHH Antibody
FIH Antibody
GPRC2A Antibody
HHC Antibody
HHC1 Antibody
Hypocalciuric hypercalcemia 1 Antibody
Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism Antibody
MGC138441 Antibody
NSHPT Antibody
Parathyroid Ca(2+) sensing receptor 1 Antibody
Parathyroid Cell calcium sensing receptor Antibody
Parathyroid Cell calcium-sensing receptor Antibody
PCAR 1 Antibody
PCaR1 Antibody
Information: Target information shown above is from the UniProt Consortium.
Please Note: Anti-Calcium Sensing Receptor Antibody (Biotin) is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | CASR-BIOTIN
Size Price Quantity
100µg £429

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