Anti-Carbonic Anhydrase 2 / CA2 Antibody (A283276)

Anti-Carbonic Anhydrase 2 / CA2 Antibody

Sheep polyclonal antibody to Carbonic Anhydrase 2 / CA2.

This antibody recognises human carbonic anhydrase II, also known as Carbonate dehydratase II or Carbonic anhydrase C. Carbonic anhydrase II is a 259 amino acid ~30 kDa enzyme essential for bone resorption and osteoclast differrentiation.Mutations in the CA2 gene has been identified as the cause of osteopetrosis, autosomal recessive 3 (OPTB3), a rare disease characterized by particularly dense bone, cerebral calcification and renal tubular acidosis (Shah et al 2004).Product identity is confirmed by double diffusion vs human CAII. No reactivity is seen in immunodiffusion against CAI.

WB, IF, Immunodiffusion

WB: 1:1,000

Human

Purified human carbonic anhydrase II (CAII) prepared from erythrocytes.

Sheep

Polyclonal

IgG

Lot Specific

Approximately 18 kDa in rat adrenomedullary chromaffin cell lysates.

Liquid

Supplied in Glycine Buffered Saline with <0.1% Sodium Azide, 0.1% EACA, 0.01% Benzamidine, and 1 mM EDTA.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Sheep anti Human carbonic anhydrase II antibody recognizes human carbonic anhydrase II, also known as Carbonate dehydratase II or Carbonic anhydrase C. Carbonic anhydrase II is a 259 amino acid ~30 kDa enzyme essential for bone resorption and osteoclast differrentiation.Mutations in the CA2 gene has been identified as the cause of osteopetrosis, autosomal recessive 3 (OPTB3), a rare disease characterized by particularly dense bone, cerebral calcification and renal tubular acidosis (Shah et al 2004).Product identity is confirmed by double diffusion vs human CAII. No reactivity is seen in immunodiffusion against CAI.