Anti-Cardiac Troponin I Antibody [596] (A278793)

Anti-Cardiac Troponin I Antibody [596]

Mouse monoclonal [596] antibody to Cardiac Troponin I.

This antibody recognises human cardiac Troponin I (cTnI). Troponin I is a 24kDa subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. recognises an epitope between amino acid residues 169 - 178 and does not cross react with skeletal TnI.

WB, ELISA, IP

Human

Mixture of free human cardiac Troponin I and native human cardiac Troponin complex.

Mouse

Monoclonal

596

IgG1

Unconjugated

Protein A affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human Troponin I (Cardiac) antibody, clone 596 recognizes human cardiac Troponin I (cTnI). Troponin I is a 24kDa subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. Mouse anti Human Troponin I (Cardiac) antibody, clone 596 recognizes an epitope between amino acid residues 169 - 178 and does not cross react with skeletal TnI.

cardiac muscle, cardiomyopathy, dilated 2A (autosomal recessive), Cardiomyopathy, familial hypertrophic, 7, included, CMD1FF, CMD2A, CMH7, cTnI, Familial hypertrophic cardiomyopathy 7, MGC116817, RCM1, Tn1, Tni, TNN I3, TNNC 1, TNNC1, TNNI3, TNNI3_HUMAN, Troponin I, Troponin I cardiac, Troponin I cardiac muscle, Troponin I cardiac muscle isoform, Troponin I type 3 cardiac, troponin I, cardiac 3, TroponinI, Ttroponin I type 3 (cardiac)