Anti-APEX1 Antibody [CPTC15] (A280134)

Anti-APEX1 Antibody [CPTC15]

Mouse anti APEX1

Mouse anti Human APEX1 antibody recognizes the apurinic/apyrimidinic endodeoxyribonuclease 1, also known as AP endonuclease class I, AP lyase or protein REF-1.Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. The APEX1 gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein (provided by RefSeq, Jul 2008).Mouse anti Human APEX1 antibody detects a band of 36 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Human, Mouse, Rat

Recombinant protein of human APEX1.

Mouse

Monoclonal

CPTC15

Protein G chromatography.

500 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

AP endonuclease 1, APE, APE-1, APEN, APEX, APEX nuclease, Apurinic-apyrimidinic endonuclease 1, APX, DNA repair nuclease/redox regulator APEX1, DNA-(apurinic or apyrimidinic site) endonuclease, HAP1, Redox factor-1, REF-1, REF1