Anti-ATF1 Antibody (A320099)

Anti-ATF1 Antibody

Rabbit polyclonal antibody to ATF1.

This antibody recognises cyclic AMP-dependent transcription factor ATF1, also known as activating transcription factor 1 or protein TREB36.ATF1 is a protein belonging to the ATF subfamily of the bZIP (basic-region leucine zipper) family involved in the regulation of the expression of genes involved in several cellular processes including cell growth and survival. The ATF1 protein is phosphorylated at serine 63 in its kinase-inducible domain by several serine/threonine kinases, including cAMP-dependent protein kinase A and cyclin-dependent kinase 3 (CDK3). Phosphorylation of ATF1 at serine 63 enhances its transactivation and transcriptional activity, thereby enhancing cell transformation.

WB: 1:500 - 1:1,000

Human

A peptide derived from within the C-terminus of human ATF1.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human ATF1 antibody recognizes cyclic AMP-dependent transcription factor ATF1, also known as activating transcription factor 1 or protein TREB36.ATF1 is a protein belonging to the ATF subfamily of the bZIP (basic-region leucine zipper) family involved in the regulation of the expression of genes involved in several cellular processes including cell growth and survival. The ATF1 protein is phosphorylated at serine 63 in its kinase-inducible domain by several serine/threonine kinases, including cAMP-dependent protein kinase A and cyclin-dependent kinase 3 (CDK3). Phosphorylation of ATF1 at serine 63 enhances its transactivation and transcriptional activity, thereby enhancing cell transformation (Zheng et al. 2008).

Activating transcription factor 1, cAMP-dependent transcription factor ATF-1, Cyclic AMP-dependent transcription factor ATF-1, Protein TREB36