Anti-ATG5-ATG12 Complex Antibody (A282968)

Anti-ATG5-ATG12 Complex Antibody

Rabbit polyclonal antibody to ATG5-ATG12 Complex.

This antibody recognises an epitope within the C-terminal (CT) region of the Atg5-Atg12 complex, which plays a key role in the regulation of autophagy, and is emerging as an important factor in the innate immune response to viruses. The Atg5-Atg12 complex interacts with retinoic acid–inducible gene 1 and the adaptor molecule IFN-beta promoter stimulator 1, through caspase recruitment domains, thereby acting as a negative regulator of the type I IFN production pathway, and as a contributor to RNA viral replication within the host cells (Takeshita et al 2008).

WB: 1.0 - 2 µg/ml

Mouse, Human

Synthetic peptide corresponding to amino acids 262-275 of mouse Atg5, conjugated to Keyhole Limpet Haemocyanin. The corresponding sequence differs by one amino acid in human.

DNFLHISIVPQPTD

Rabbit

Polyclonal

IgG

1 mg/ml

Approximately 56 kDa in mouse liver and human U87 cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti ATG5-ATG12 Complex antibody recognizes an epitope within the C-Terminal (CT) region of the Atg5-Atg12 complex, which plays a key role in the regulation of autophagy, and is emerging as an important factor in the innate immune response to viruses (Hwang et al. 2012).The Atg5-Atg12 complex interacts with retinoic acid–inducible gene 1 and the adaptor molecule IFN-beta promoter stimulator 1, through caspase recruitment domains, thereby acting as a negative regulator of the type I IFN production pathway, and as a contributor to RNA viral replication within the host cells (Takeshita et al 2008).