Anti-BAFF Antibody [2B] - BSA and Azide free (A279179)

Anti-BAFF Antibody [2B] - BSA and Azide free

Mouse monoclonal [2B] antibody to BAFF.

This antibody recognises CD257, also known as BAFF/BLyS. CD257 is a 285 amino acid type II transmembrane protein and member of the tumor necrosis factor (TNF) superfamily of ligands, which acts as a B and T cell stimulator and plays a role in the development of autoimmune diseases such as systemic lupus erythematosus. CD257 is expressed by monocytes, macrophages, T cells and dendritic cells and acts through binding to CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells. Mouse anti Human CD257 antibody, clone 2B has not been cross-adsorbed and may react with homologous proteins from related species.

ELISA: 5 - 6 µg/ml

Human

Recombinant 17 kDa polypeptide corresponding to the TNF-like portion of the extracellular domain of human CD257, expressed in E. coli.

Mouse

Monoclonal

2B

IgG1

Protein G affinity chromatography of tissue culture supernatant.

Lyophilized

Reconstitute with 0.5 ml of distilled water.

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD257 antibody, clone 2B recognises CD257, also known as BAFF/BLyS. CD257 is a 285 amino acid type II transmembrane protein and member of the tumor necrosis factor (TNF) superfamily of ligands, which acts as a B and T cell stimulator and plays a role in the development of autoimmune diseases such as systemic lupus erythematosus. CD257 is expressed by monocytes, macrophages, T cells and dendritic cells and acts through binding to CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells. Mouse anti Human CD257 antibody, clone 2B has not been cross-adsorbed and may react with homologous proteins from related species.

B lymphocyte stimulator, B-cell-activating factor, BLYS, CD257, Dendritic cell-derived TNF-like molecule, TALL-1, TALL1, TNF- and APOL-related leukocyte expressed ligand 1, TNFSF13B, TNFSF20, Tumor necrosis factor ligand superfamily member 13B, ZTNF4