Anti-BAP1 Antibody (A320100)

Anti-BAP1 Antibody

Rabbit polyclonal antibody to BAP1.

This antibody recognises bAP1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), also known as BRCA1-associated protein 1 or cerebral protein 6.BAP1 localizes to the nucleus where it acts as a deubiquitinase due to its ubiquitin carboxy-terminal hydrolase (UCH) domain. BAP1 is a member of the polycomb-group proteins (PcGs). PcGs are a group of highly conserved transcriptional repressors required for long-term silencing of genes that regulate various processes including cell fate determination, and stem cell pluripotency (Gaytán de Ayala Alonso et al. 2007). BAP1 functions as a tumor suppressor and mutations in the BAP1 gene may be linked to the development of a number of different cancers including malignant mesothelioma.

WB: 1:500 - 1:2,000

Human, Mouse

A peptide derived from within the C-terminus of human BAP1.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human BAP1 antibody recognizes BAP1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), also known as BRCA1-associated protein 1 or cerebral protein 6.BAP1 localizes to the nucleus where it acts as a deubiquitinase due to its ubiquitin carboxy-terminal hydrolase (UCH) domain (Jensen et al. 1998). BAP1 is a member of the polycomb-group proteins (PcGs). PcGs are a group of highly conserved transcriptional repressors required for long-term silencing of genes that regulate various processes including cell fate determination, and stem cell pluripotency (Gaytán de Ayala Alonso et al. 2007). BAP1 functions as a tumor suppressor and mutations in the BAP1 gene may be linked to the development of a number of different cancers including malignant mesothelioma (Cheung and Testa, 2017).

BRCA1-associated protein 1, Cerebral protein 6, KIAA0272, Ubiquitin carboxyl-terminal hydrolase BAP1