Anti-Brk / PTK6 Antibody (A283711)

Anti-Brk / PTK6 Antibody

Rabbit polyclonal antibody to Brk / PTK6.

This antibody recognises protein-tyrosine kinase 6, also known as breast tumor kinase and tyrosine-protein kinase BRK. PTK6 is a nonreceptor tyrosine kinase that is evolutionarily related to the FRK family of kinases and more distantly to the SRC family of tyrosine kinases (Qui and Miller 2002, Brauer and Tyner 2010). It controls various signaling pathways involved in the differentiation and maintenance of normal epithelia. PTK6 substrates include AKT , SLM1 and SLM2 , STAT3 , STAT5b. PTK6 is coamplified and coexpressed with ErbB2 in human breast cancers to promote proliferation.

WB: 1:500 - 1:2,000

Human, Rat, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 222-451 of human PTK6.

SRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT

Rabbit

Polyclonal

IgG

Lot Specific

Approximately 60 kDa in various cell and tissue lysates under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti PTK6 antibody recognizes protein-tyrosine kinase 6, also known as breast tumor kinase and tyrosine-protein kinase BRK. PTK6 is a nonreceptor tyrosine kinase that is evolutionarily related to the FRK family of kinases and more distantly to the SRC family of tyrosine kinases (Qui and Miller 2002, Brauer and Tyner 2010). It controls various signaling pathways involved in the differentiation and maintenance of normal epithelia (Brauer and Tyner 2010). PTK6 substrates include AKT (Zhang et al. 2005), SLM1 and SLM2 (Haegebarth et al. 2004), STAT3 (Liu et al. 2006), STAT5b (Weaver and Silva 2007). PTK6 is coamplified and coexpressed with ErbB2 in human breast cancers to promote proliferation (Xiang et al. 2008).