Anti-C-Peptide Antibody [CC34] (A280047)

Anti-C-Peptide Antibody [CC34]

Mouse monoclonal [CC34] antibody to C-Peptide.

This antibody recognises rat C-peptide. C-peptide is a 31 amino acid peptide released when proinsulin is split into insulin and C-peptide. In rats, two isoforms of proinsulin exists, the difference is two amino acid residues in the C-peptide, termed C-peptide I and C-peptide II. Proinsulin is split when it is released from the pancreas into the blood in response to a rise in serum glucose levels. C-peptide function is not fully understood, it binds to cell membranes which leads to increased intracellular Ca2+ concentration and subsequent stimulation of N+, K+-ATPase and endothelial nitric oxide synthase activities. C-peptide also functions in repair of the muscular layer of arteries. recognises rat and mouse C-peptide I and rat C-peptide II with equal affinity. It reacts weakly with mouse C-peptide II. It does not recognize rat proinsulin.

Rat, Mouse

Fragments of rat C-peptide conjugated to a carrier protein.

Mouse

Monoclonal

CC34

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Rat C-Peptide antibody, clone CC34 recognizes rat C-peptide. C-peptide is a 31 amino acid peptide released when proinsulin is split into insulin and C-peptide. In rats, two isoforms of proinsulin exists, the difference is two amino acid residues in the C-peptide, termed C-peptide I and C-peptide II. Proinsulin is split when it is released from the pancreas into the blood in response to a rise in serum glucose levels. C-peptide function is not fully understood, it binds to cell membranes which leads to increased intracellular Ca2+ concentration and subsequent stimulation of N+, K+-ATPase and endothelial nitric oxide synthase activities. C-peptide also functions in repair of the muscular layer of arteries. Mouse anti Rat C-Peptide antibody, clone CC34 recognizes rat and mouse C-peptide I and rat C-peptide II with equal affinity. It reacts weakly with mouse C-peptide II. It does not recognize rat proinsulin.