Anti-Carabin Antibody (A283135)

Anti-Carabin Antibody

Rabbit polyclonal antibody to Carabin.

This antibody recognises the N-terminal region of human Carabin, also known as TBC1 domain family member 10C (TBC1D10C), a 50 kDa protein belonging to the TBC1 domain family of proteins.Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway and acts as an inhibitor of the Ras signaling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras.Carabin is most abundantly expressed in spleen and peripheral blood leucocytes. Rabbit anti Human Carabin antibody (AHP1486) does not cross react with either TBC1D10A or TBC1D10B.

WB, IHC-P

WB: 1 - 2 µg/ml

Human, Mouse

A peptide corresponding to 17 amino acids near the N-terminus of human Carabin.

Rabbit

Polyclonal

IgG

Approximately 55 kDa in human spleen tissue cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human Carabin antibody recognizes the N-terminal region of human Carabin, also known as TBC1 domain family member 10C (TBC1D10C), a 50 kDa protein belonging to the TBC1 domain family of proteins. Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway and acts as an inhibitor of the Ras signaling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leucocytes. Rabbit anti Human Carabin antibody (AHP1486) does not cross react with either TBC1D10A or TBC1D10B.

TBC1 domain family member 10C, TBC1D10C