Anti-CBFB Antibody [PCRP-CBFB-1F6] - BSA and Azide free (A278424)

Anti-CBFB Antibody [PCRP-CBFB-1F6] - BSA and Azide free

Mouse monoclonal [PCRP-CBFB-1F6] antibody to CBFB.

The transcription factor polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (osteoblast-specific transcription factor), CBFA1 (core binding factor) and AML3 (acute myeloid leukemia), is composed of two subunits, α and β, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2α subunits, PEBP2αA, PEBP2αB and PEBP2αC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, Runt. This region is involved in DNA binding and heterodimerization with the regulatory β subunit, which facilitates DNA binding of the α subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2β is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle Myosin heavy chain, producing a chimeric gene, PEBP2β/CBFB-SMMHC, that is associated with human acute myeloid leukemia.

ELISA, WB, IP, Flow Cytometry, IF

WB: 1-2 µg/ml, IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Recombinant full-length human CBFB protein.

Mouse

Monoclonal

PCRP-CBFB-1F6

IgG2b

Protein A/G chromatography.

1 mg/ml

22 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CBFB Antibody [PCRP-CBFB-1F6] (A277836).

CBF-beta, Core-binding factor subunit beta, PEA2-beta, PEBP2-beta, Polyomavirus enhancer-binding protein 2 beta subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit