Anti-CCL27 Antibody [A01-2H4] (A279580)

Anti-CCL27 Antibody [A01-2H4]

Mouse monoclonal [A01-2H4] antibody to CCL27.

This antibody recognises C-C motif chemokine 27, also known as CTACK, ESkine, ILC, and SCYA27. CCL27 is a C-C motif chemokine. CCR10 is the only known receptor for CCL27, and is expressed in normal skin. CCL27 is able to attract a subset of memory / effector T cells from peripheral blood to specific locations on the skin. CCL27 plays a role in T cell mediated skin inflammation, and high levels have been found in patients with psoraisis and atopic dermatitis. Upregulation of CCL27 has been identified in patients with myeloma, and is correlated with poor overall survival. CCL27 is secreted by primary tumor cells with high metastatic potential and is able to attract lymphatic endothelial cells, a crucial process during lymphangiogenesis. This purified Mouse anti Human CCL27 antibody, clone A01-2H4 (MCA6184GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL27 antibody, clone B05-10H9 (MCA6185B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CCL27 (Phe25-Gly112).

Mouse

Monoclonal

A01-2H4

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CCL27 antibody, clone A01-2H4, recognizes C-C motif chemokine 27, also known as CTACK, ESkine, ILC, and SCYA27. CCL27 is a C-C motif chemokine. CCR10 is the only known receptor for CCL27, and is expressed in normal skin (Mao et al. 2018). CCL27 is able to attract a subset of memory / effector T cells from peripheral blood to specific locations on the skin (Wang et al. 2018). CCL27 plays a role in T cell mediated skin inflammation, and high levels have been found in patients with psoraisis and atopic dermatitis. Upregulation of CCL27 has been identified in patients with myeloma, and is correlated with poor overall survival (Thangavadivel et al. 2016). CCL27 is secreted by primary tumor cells with high metastatic potential and is able to attract lymphatic endothelial cells, a crucial process during lymphangiogenesis (Karnezis et al. 2019).This purified Mouse anti Human CCL27 antibody, clone A01-2H4 (MCA6184GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL27 antibody, clone B05-10H9 (MCA6185B) as the detection antibody.

C-C motif chemokine 27, CC chemokine ILC, CTACK, Cutaneous T-cell-attracting chemokine, ESkine, IL-11 R-alpha-locus chemokine, ILC, SCYA27, Skinkine, Small-inducible cytokine A27