Anti-CCL27 Antibody [B05-10H9] (Biotin) (A279732)

Anti-CCL27 Antibody [B05-10H9] (Biotin)

Mouse monoclonal [B05-10H9] antibody to CCL27 (Biotin).

This antibody recognises C-C motif chemokine 27, also known as CTACK, ESkine, ILC, and SCYA27. CCL27 is a C-C motif chemokine. CCR10 is the only known receptor for CCL27, and is expressed in normal skin. CCL27 is able to attract a subset of memory / effector T cells from peripheral blood to specific locations on the skin. CCL27 plays a role in T cell mediated skin inflammation, and high levels have been found in patients with psoraisis and atopic dermatitis. Upregulation of CCL27 has been identified in patients with myeloma, and is correlated with poor overall survival. CCL27 is secreted by primary tumor cells with high metastatic potential and is able to attract lymphatic endothelial cells, a crucial process during lymphangiogenesis. This biotinylated Mouse anti Human CCL27 antibody, clone B05-10H9 (MCA6185B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL27 antibody, clone A01-2H4 (MCA6184GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CCL27 (Phe25-Gly112).

Mouse

Monoclonal

B05-10H9

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CCL27 antibody, clone B05-10H9 recognizes C-C motif chemokine 27, also known as CTACK, ESkine, ILC, and SCYA27. CCL27 is a C-C motif chemokine. CCR10 is the only known receptor for CCL27, and is expressed in normal skin (Mao et al. 2018). CCL27 is able to attract a subset of memory / effector T cells from peripheral blood to specific locations on the skin (Wang et al. 2018). CCL27 plays a role in T cell mediated skin inflammation, and high levels have been found in patients with psoraisis and atopic dermatitis. Upregulation of CCL27 has been identified in patients with myeloma, and is correlated with poor overall survival (Thangavadivel et al. 2016). CCL27 is secreted by primary tumor cells with high metastatic potential and is able to attract lymphatic endothelial cells, a crucial process during lymphangiogenesis (Karnezis et al. 2019).This biotinylated Mouse anti Human CCL27 antibody, clone B05-10H9 (MCA6185B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL27 antibody, clone A01-2H4 (MCA6184GA) as the capture antibody.

C-C motif chemokine 27, CC chemokine ILC, CTACK, Cutaneous T-cell-attracting chemokine, ESkine, IL-11 R-alpha-locus chemokine, ILC, SCYA27, Skinkine, Small-inducible cytokine A27

This product is for research use only. It is not intended for diagnostic or therapeutic use.