Anti-CD1d Antibody [WTH1] (A282000)

Anti-CD1d Antibody [WTH1]

Mouse anti Rat CD1d antibody, clone WTH1 recognizes rat CD1d, a glycoprotein expressed on cortical thymocytes, certain T-cell leukaemias and various other antigen presenting cells. CD1d binds self and non-self glycolipids and presents them to T-cell receptors on natural killer cells. When activated, natural killer cells produce Th1 and Th2 cytokines.Clone WTH1 binds with high affinity to the mature CD1d heavy chain independently of beta-2-microglobulin. Mouse anti Rat CD1d antibody, clone WTH1 efficiently blocks rat and mouse invariant natural killer T cell (iNKT cell) response to a-GalCer (an antigen for iNKT cells) and has a slightly higher affinity to native CD1d than clone WTH2.Clone WTH1 cross reacts weakly with mouse tissue in IHC and western blotting, but reacts strongly with both rat and mouse antigens in flow cytometry and immunoprecipitation.

WB, ELISA, Functional Studies, Flow Cytometry, IHC-Fr, IP

Rat, Mouse

Rat CD1d-transduced M12.4.1.C3 cells.

Mouse

Monoclonal

WTH1

IgG2a

Protein A chromatography.

500 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with < 0.1% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Antigen-presenting glycoprotein CD1d, R3G1