Anti-CD30 Antibody [D02-6E11] (Biotin) (A280195)

Anti-CD30 Antibody [D02-6E11] (Biotin)

Mouse monoclonal [D02-6E11] antibody to CD30 (Biotin).

This antibody recognises CD30 also known as Tumor Necrosis Factor Receptor Super Family member 8, CD30L receptor and Ki-1 antigen. CD30 is a 120 kDa transmembrane glycoprotein that belongs to the tumor necrosis factor receptor superfamily. CD30 is expressed on small subsets of activated T and B lymphocytes and a range of lymphoid neoplasms. Upon binding of its ligand CD30L, CD30 undergoes trimerization and recruits TNFR-associated factor (TRAF) and TRAF binding proteins generating a signaling complex which can then mediate MAPK and NF?B signaling. In this way, CD30 signaling is able to regulate peripheral T cell responses, controls T cell survival, down regulates cytolitic capacity and regulates thymocyte survival. The biotinylated Mouse anti Human CD30 antibody, clone D02-6E11 (MCA6271B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CD30 antibody, clone G05-2D2 (MCA6270GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CD30 (Phe19-Lys595).

Mouse

Monoclonal

D02-6E11

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CD30 antibody, clone D02-6E11, recognizes CD30 also known as Tumor Necrosis Factor Receptor Super Family member 8, CD30L receptor and Ki-1 antigen. CD30 is a 120 kDa transmembrane glycoprotein that belongs to the tumor necrosis factor receptor superfamily. CD30 is expressed on small subsets of activated T and B lymphocytes and a range of lymphoid neoplasms (Weyden et al. 2017). Upon binding of its ligand CD30L, CD30 undergoes trimerization and recruits TNFR-associated factor (TRAF) and TRAF binding proteins generating a signaling complex which can then mediate MAPK and NF?B signaling (Weyden et al. 2017). In this way, CD30 signaling is able to regulate peripheral T cell responses, controls T cell survival, down regulates cytolitic capacity and regulates thymocyte survival (Muta & Podack 2013).The biotinylated Mouse anti Human CD30 antibody, clone D02-6E11 (MCA6271B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CD30 antibody, clone G05-2D2 (MCA6270GA) as the capture antibody.

CD30L receptor, D1S166E, Ki-1 antigen, Lymphocyte activation antigen CD30, TNFRSF8, Tumor necrosis factor receptor superfamily member 8

This product is for research use only. It is not intended for diagnostic or therapeutic use.