Anti-CD6 / T12 Antibody [MEM-98] (FITC) (A281170)

Anti-CD6 / T12 Antibody [MEM-98] (FITC)

Mouse monoclonal [MEM-98] antibody to CD6 / T12 (FITC).

This antibody recognises human CD6, also known as T12 or TP120. CD6 is a ~100-130 kDa type 1 single pass trans-membrane protein member of the immunoglobulin superfamily. CD6 possesses 3 scavenger receptor cysteine rich (SRCR) domains in it’s extracellular sequence. The membrane proximal SRCR3 contains the epitope responsible for interaction with CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166. Multiple gene transcripts have been detected encoding CD6 in man resulting in the production of a number of CD6 isoforms. recognises an external epitope located in the membrane-distal SRCR domain 1 and is expected to recognize all CD6 isoforms so far identified, CD6A-E.CD6 has been implicated as a therapeutic target for a number of autoimmune conditions including Sjögren's syndrome , rheumatoid arthritis (Rodriguez et al.) and psoriasis.

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 10⁶ cells or 100µl whole blood

Human

Purified CD6 antigen.

Mouse

Monoclonal

MEM-98

Protein A affinity chromatography of ascites.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CD6 antibody, clone MEM-98 recognizes human CD6, also known as T12 or TP120. CD6 is a ~100-130 kDa type 1 single pass trans-membrane protein member of the immunoglobulin superfamily. CD6 possesses 3 scavenger receptor cysteine rich (SRCR) domains in it’s extracellular sequence. The membrane proximal SRCR3 contains the epitope responsible for interaction with CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166. Multiple gene transcripts have been detected encoding CD6 in man resulting in the production of a number of CD6 isoforms. Mouse anti human CD6, clone MEM-98 recognizes an external epitope located in the membrane-distal SRCR domain 1 and is expected to recognize all CD6 isoforms so far identified, CD6A-E.CD6 has been implicated as a therapeutic target for a number of autoimmune conditions (Pinto et al. 2013) including Sjögren's syndrome (Ramos-Casals et al. 2001) , rheumatoid arthritis (Rodriguez et al.) and psoriasis (Wilsmann-Theis et al. 2006).

This product is for research use only. It is not intended for diagnostic or therapeutic use.