Anti-Cdk8 Antibody (A320104)

Anti-Cdk8 Antibody

Rabbit polyclonal antibody to Cdk8.

This antibody recognises cell division protein kinase 8, also known as cell division protein kinase 8 or mediator complex subunit CDK8.CDK8 is a 53 kDa is a member of the cyclin-dependent protein kinase (CDK) family involved in transcriptional regulation via interaction with the mediator complex. CDK8 regulates the activity of several transcription factors via its kinase activity, including STAT1. CDK8 is also able to inhibit transcriptional activation by influencing the turnover of subunits in the mediator complex tail module and mediating the binding of RNA polymerase II to the mediator complex. Expression of CDK8 may contribute to the development of a number of different types of cancer (Firestein et al. 2008, Donner et al. 2007).

ChIP, WB

ChIP: 10 µl per ChIP, WB: 1:500 - 1:1500

Human, Mouse

A peptide derived from within the C-terminus of human CDK8.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human CDK8 antibody recognizes cell division protein kinase 8, also known as cell division protein kinase 8 or mediator complex subunit CDK8.CDK8 is a 53 kDa is a member of the cyclin-dependent protein kinase (CDK) family involved in transcriptional regulation via interaction with themediator complex (Tassan et al. 1995). CDK8 regulates the activity of severaltranscription factors via its kinase activity, including STAT1 (Bancerek et al. 2013). CDK8 is also able to inhibit transcriptional activation by influencingthe turnoverof subunits in the mediator complex tail module and mediating the binding ofRNA polymerase IIto the mediator complex (Tsai et al. 2013). Expression of CDK8 may contribute to the development of a number of different types of cancer (Firestein et al. 2008, Donner et al. 2007).

Cell division protein kinase 8, Cyclin-dependent kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35