Anti-CEACAM1 + CEACAM3 + CEACAM6 Antibody [YTH71.3] (A282091)

Anti-CEACAM1 + CEACAM3 + CEACAM6 Antibody [YTH71.3]

Rat monoclonal [YTH71.3] antibody to CEACAM1 + CEACAM3 + CEACAM6 .

This antibody recognises 3 members of the human CD66 family, namely CD66a, also known as Carcinoembryonic antigen-related cell adhesion molecule 1, Biliary glycoprotein 1 or CEACAM1. Clone YTH71.3 also recognises CD66c, known as Carcinoembryonic antigen-related cell adhesion molecule 6 or Non-specific crossreacting antigen. In addition the clone also recognises CD66d which in turn is also known as Carcinoembryonic antigen-related cell adhesion molecule 3 or CGM1. CD66 family members are single pass, type 1 membrane glycoproteins bearing a single V-type Ig-like domain and a varying number of C2-type Ig-like domains. Clone YTH71.3 recognises epitopes in the N-terminal domain of these CD66 family members.CD66 members are expressed by human neutrophils and cells of the colon where it is down regulated in some cases of colon carcinoma. CD66a is also expressed in the human alveolar adenocarcinoma cell line A549 and may play a role in Moraxella catarrhalis induced apoptosis of pulmonary epithlial cells in diseases including COPD and emphysema (N'Guessan et al. 2007).

IHC-P, Flow Cytometry, IHC-Fr

IHC-P: 10 µg/ml, Use 10µl of the suggested working dilution to label 1 x 10⁶ cells in 100µl.

Human, Rhesus Monkey

This antibody does not cross react with Mouse

Human lymphocytes.

Rat

Monoclonal

YTH71.3

IgG2a

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rat anti Human CD66acd antibody, clone YTH71.3 recognizes 3 members of the human CD66 family, namely CD66a, also known as Carcinoembryonic antigen-related cell adhesion molecule 1, Biliary glycoprotein 1 or CEACAM1. Clone YTH71.3 also recognizes CD66c, known as Carcinoembryonic antigen-related cell adhesion molecule 6 or Non-specific crossreacting antigen. In addition the clone also recognizes CD66d which in turn is also known as Carcinoembryonic antigen-related cell adhesion molecule 3 or CGM1 (Watt et al. 1991). CD66 family members are single pass, type 1 membrane glycoproteins bearing a single V-type Ig-like domain and a varying number of C2-type Ig-like domains. Clone YTH71.3 recognizes epitopes in the N-terminal domain of these CD66 family members.CD66 members are expressed by human neutrophils and cells of the colon where it is down regulated in some cases of colon carcinoma (Neumaier et al. 2012). CD66a is also expressed in the human alveolar adenocarcinoma cell line A549 and may play a role in Moraxella catarrhalis induced apoptosis of pulmonary epithlial cells in diseases including COPD and emphysema (N'Guessan et al. 2007).