Anti-CLEC10A Antibody [ER-MP23] (PE) (A320255)

Anti-CLEC10A Antibody [ER-MP23] (PE)

Rat monoclonal [ER-MP23] antibody to CLEC10A (PE).

This antibody recognises mouse CD301, a ~38 kDa cell surface protein, otherwise known as macrophage galactose N-acetylgalactosamine lectin (MGL) or dendritic cell asialoglycoprotein (DC-ASGPR).In mice, CD301 is predominantly expressed on mature macrophages found associated with a wide range of connective tissues including macrophages in the dermis and the pancreas. Clone ER-MP23 also detects a population of dendritic cells in lymphoid tissue, which are probably recent immigrants from peripheral connective tissue sites. Expression of CD301 is induced by alternative (i.e. IL-4/IL-13 mediated) activation of macrophages and dendritic cells, but not all CD301 positive cells are necessarily IL-4/IL-13 stimulated.Rat anti Mouse CD301 antibody, clone ER-MP23 is reported to block the function of mouse CD301. Rat anti Mouse CD301 antibody, clone ER-MP23 binds both MGL1 and MGL2 homologues.

Flow Cytometry: Neat - 1:5, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Mouse

BALB/c macrophage precursor cell hybrids.

Rat

Monoclonal

ER-MP23

IgG2a

Protein G affinity chromatography of tissue culture supernatant.

Reconstitution dependent.

Lyophilized

Reconstitute with 1 ml of distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix after reconstitution.

Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.

Lyophilized: Store at 4°C. Reconstituted: Store undiluted at 4°C. Do not freeze!

Rat anti Mouse CD301 antibody, clone ER-MP23 recognizes murine CD301, a ~38 kDa cell surface protein, otherwise known as macrophage galactose N-acetylgalactosamine lectin (MGL) or dendritic cell asialoglycoprotein (DC-ASGPR).In mice, CD301 is predominantly expressed on mature macrophages found associated with a wide range of connective tissues including macrophages in the dermis and the pancreas. Clone ER-MP23 also detects a population of dendritic cells in lymphoid tissue, which are probably recent immigrants from peripheral connective tissue sites. Expression of CD301 is induced by alternative (i.e. IL-4/IL-13 mediated) activation of macrophages and dendritic cells, but not all CD301 positive cells are necessarily IL-4/IL-13 stimulated.Rat anti Mouse CD301 antibody, clone ER-MP23 is reported to block the function of mouse CD301 (Dupasquier et al. 2006). Rat anti Mouse CD301 antibody, clone ER-MP23 binds both MGL1 and MGL2 homologues.

C-type lectin domain family 10 member A, C-type lectin superfamily member 14, CD301, CLECSF13, CLECSF14, HML, Macrophage lectin 2

This product is for research use only. It is not intended for diagnostic or therapeutic use.