Anti-CLEC4C Antibody [CLEC4C/3400] - BSA and Azide free (A316179)

Anti-CLEC4C Antibody [CLEC4C/3400] - BSA and Azide free

Mouse monoclonal [CLEC4C/3400] antibody to CLEC4C.

Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.

Human lymph node, spleen or testis.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-250) of human CLEC4C protein. The exact sequence is proprietary.

Mouse

Monoclonal

CLEC4C/3400

kappa

Protein A/G chromatography.

1 mg/ml

25 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

BDCA-2, BDCA2, Blood dendritic cell antigen 2, C-type lectin domain family 4 member C, C-type lectin superfamily member 7, CD303, CLECSF11, CLECSF7, Dendritic lectin, DLEC, HECL