Anti-COMP / Cartilage Oligomeric Matrix Protein Antibody [MA37C94 (HC484D1)] (A281010)

Anti-COMP / Cartilage Oligomeric Matrix Protein Antibody [MA37C94 (HC484D1)]

Rat monoclonal [MA37C94 (HC484D1)] antibody to COMP / Cartilage Oligomeric Matrix Protein.

This antibody recognises human cartilage oligomeric matrix protein (COMP), otherwise known as thrombospondin-5 (TSP-5). COMP is a 757 amino acid matrix glycoprotein bearing four EGF-like domains, a single TSP C-terminal domain and eight TSP type-3 repeats (Uniprot P49747). Defects in the COMP gene can lead to the presence of pseudoachondroplasia or multiple epiphyseal dysplasia. recognises an epitope located in the central portion of the molecule and has been described as suitable for use in western blotting and immunohistochemistry.

WB, IHC-P, IP, IHC-Fr, ELISA

WB: 1:200 - 1:2,000

Human

Human cartilage derived COMP.

Rat

Monoclonal

MA37C94 (HC484D1)

IgG2a

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rat anti Human cartilage oligomeric matrix protein antibody, clone MA37C94 recognizes human cartilage oligomeric matrix protein (COMP), otherwise known as thrombospondin-5 (TSP-5). COMP is a 757 amino acid matrix glycoprotein bearing four EGF-like domains, a single TSP C-terminal domain and eight TSP type-3 repeats (Uniprot P49747). Defects in the COMP gene can lead to the presence of pseudoachondroplasia or multiple epiphyseal dysplasia (Posey et al. 2014). Rat anti Human cartilage oligomeric matrix protein, clone MA37C94 recognizes an epitope located in the central portion of the molecule and has been described as suitable for use in western blotting (Gagarina et al. 2008) and immunohistochemistry (Grigoriadis et al. 2006).