Mouse monoclonal [032B-22.1.X] antibody to Complement Factor Bb.
Specificity
This antibody recognises a neoantigen of the Bb fragment of human complement factor B.
Applications
ELISA
Reactivity
Human
Immunogen
Purified human factor B.
Host
Mouse
Clonality
Monoclonal
Clone ID
032B-22.1.X
Isotype
IgG2a
Conjugate
Unconjugated
Purification
Protein A affinity chromatography of ascites.
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Borate Buffered Saline with <0.1% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Factor B is present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit) leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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