Anti-CXCL10 / IP-10 Antibody [D03-4F4] (Biotin) (A280198)

Anti-CXCL10 / IP-10 Antibody [D03-4F4] (Biotin)

Mouse monoclonal [D03-4F4] antibody to CXCL10 / IP-10 (Biotin).

This antibody recognises Chemokine C-X-C ligand 10 (CXCL10), also known as interferon-?-inducible protein 10 (IP-10), is a member of the C-X-C subfamily of chemokines. CXCL10 can be secreted by leukocytes, neutrophils, monocytes, endothelial cells, fibroblasts, thyrocytes and keratinocytes. CXCL10 plays a role in the recruitment of immune cells expressing its specific receptor, CXCR3. Beyond regulating immune cell migration, CXCL10 also plays a role in regulating cell growth and angiogenesis inhibition during tissue injury, development and maintenance.Under normal physiological conditions, CXCL10 is usually undetectable in most non-lymphoid tissues. Only upon induction of an immunoinflammatory response through infection or injury is CXCL10 then detected. As such, CXCL10 has been used as a biomarker of disease severity and as a prognostic indicator for various renal diseases. This biotinylated Mouse anti Human CXCL10 antibody, clone D03-4F4 (MCA6189B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CXCL10 antibody, clone A01-2G1 (MCA6188GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CXCL10 (Val22-Pro98).

Mouse

Monoclonal

D03-4F4

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CXCL10 antibody, clone D03-4F4, recognizes Chemokine C-X-C ligand 10 (CXCL10), also known as interferon-?-inducible protein 10 (IP-10), is a member of the C-X-C subfamily of chemokines. CXCL10 can be secreted by leukocytes, neutrophils, monocytes, endothelial cells, fibroblasts, thyrocytes and keratinocytes. CXCL10 plays a role in the recruitment of immune cells expressing its specific receptor, CXCR3. Beyond regulating immune cell migration, CXCL10 also plays a role in regulating cell growth and angiogenesis inhibition during tissue injury, development and maintenance. Under normal physiological conditions, CXCL10 is usually undetectable in most non-lymphoid tissues. Only upon induction of an immunoinflammatory response through infection or injury is CXCL10 then detected (Muller et al. 2010). As such, CXCL10 has been used as a biomarker of disease severity and as a prognostic indicator for various renal diseases (Gao et al. 2020).This biotinylated Mouse anti Human CXCL10 antibody, clone D03-4F4 (MCA6189B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CXCL10 antibody, clone A01-2G1 (MCA6188GA) as the capture antibody.

This product is for research use only. It is not intended for diagnostic or therapeutic use.