Anti-CXCL16 Antibody - BSA and Azide free (A283745)

Anti-CXCL16 Antibody - BSA and Azide free

Rabbit polyclonal antibody to CXCL16.

This antibody recognises C-X-C motif Chemokine 16 (CXCL16). Unlike most chemokines, CXCL16 is a membrane bound ligand anchored through transmembrane domains. Although a soluble form of CXCL16 is generated through proteolytic cleavage. Transmembrane CXCL16 is mainly expressed on macrophages, dendritic cells, B cells and various tumor cells. In this form, it acts as an adhesion molecule though the binding of its receptor CXCR6 expressed on other cells including T cells. Transmembrane CXCL16 also binds gram positive and gram negative bacteria, playing a role in innate and adaptive immune responses. Soluble CXCL16 has chemoattractant activity, and elicits this response through the receptor CXCR6 and plays a role in tumor progression. CXCL16 may be used as a biomarker for the evaluation of some tumor type prognoses (Richardsen et al. 2015, Shibata et al. 2020, Gooden et al. 2014).

WB, ELISA

ELISA: 0.5 µg/ml - 2.0 µg/ml, WB: 0.1 µg/ml - 0.2 µg/ml

Human

E. coli derived recombinant human CXCL16.

Rabbit

Polyclonal

IgG

Lyophilized

Reconstitute with 0.1 ml of distilled water.

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti Human CXCL16 antibody, recognizes C-X-C motif Chemokine 16 (CXCL16). Unlike most chemokines, CXCL16 is a membrane bound ligand anchored through transmembrane domains. Although a soluble form of CXCL16 is generated through proteolytic cleavage. Transmembrane CXCL16 is mainly expressed on macrophages, dendritic cells, B cells and various tumor cells. In this form, it acts as an adhesion molecule though the binding of its receptor CXCR6 expressed on other cells including T cells. Transmembrane CXCL16 also binds gram positive and gram negative bacteria, playing a role in innate and adaptive immune responses (Shimaoka et al. 2003). Soluble CXCL16 has chemoattractant activity, and elicits this response through the receptor CXCR6 and plays a role in tumor progression. CXCL16 may be used as a biomarker for the evaluation of some tumor type prognoses (Richardsen et al. 2015, Shibata et al. 2020, Gooden et al. 2014).

C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, SCYB16, Small-inducible cytokine B16, SR-PSOX, SRPSOX, Transmembrane chemokine CXCL16