Anti-CXCL16 Antibody [C19-5F9] (Biotin) (A279949)

Anti-CXCL16 Antibody [C19-5F9] (Biotin)

Mouse monoclonal [C19-5F9] antibody to CXCL16 (Biotin).

This antibody recognises C-X-C motif Chemokine 16 (CXCL16). Unlike most chemokines, CXCL16 is a membrane bound ligand anchored through transmembrane domains. Although a soluble form of CXCL16 is generated through proteolytic cleavage. Transmembrane CXCL16 is mainly expressed on macrophages, dendritic cells, B cells and various tumor cells. In this form, it acts as an adhesion molecule though the binding of its receptor CXCR6 expressed on other cells including T cells. Transmembrane CXCL16 also binds gram positive and gram negative bacteria, playing a role in innate and adaptive immune responses. Soluble CXCL16 has chemoattractant activity, and elicits this response through the receptor CXCR6.CXCL16 may alos play a role in tumor progression and serve as a biomarker for the evaluation of some tumor type prognoses (Richardsen et al. 2015, Shibata et al. 2020, Gooden et al. 2014).The biotinylated Mouse anti Human CXCL16 antibody, clone C19-5F9 (MCA6223B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CXCL16 antibody, clone B06-3H6 (MCA6222GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CXCL16 (Asn49-Pro137).

Mouse

Monoclonal

C19-5F9

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CXCL16 antibody, clone C19-5F9, recognizes C-X-C motif Chemokine 16 (CXCL16). Unlike most chemokines, CXCL16 is a membrane bound ligand anchored through transmembrane domains. Although a soluble form of CXCL16 is generated through proteolytic cleavage. Transmembrane CXCL16 is mainly expressed on macrophages, dendritic cells, B cells and various tumor cells. In this form, it acts as an adhesion molecule though the binding of its receptor CXCR6 expressed on other cells including T cells. Transmembrane CXCL16 also binds gram positive and gram negative bacteria, playing a role in innate and adaptive immune responses (Shimaoka et al. 2003). Soluble CXCL16 has chemoattractant activity, and elicits this response through the receptor CXCR6.CXCL16 may alos play a role in tumor progression and serve as a biomarker for the evaluation of some tumor type prognoses (Richardsen et al. 2015, Shibata et al. 2020, Gooden et al. 2014).The biotinylated Mouse anti Human CXCL16 antibody, clone C19-5F9 (MCA6223B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CXCL16 antibody, clone B06-3H6 (MCA6222GA) as the capture antibody.

C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, SCYB16, Small-inducible cytokine B16, SR-PSOX, SRPSOX, Transmembrane chemokine CXCL16

This product is for research use only. It is not intended for diagnostic or therapeutic use.