Anti-CXCL9 Antibody [C04-3E4] (A279934)

Anti-CXCL9 Antibody [C04-3E4]

Mouse monoclonal [C04-3E4] antibody to CXCL9.

This antibody recognises C-X-C motif chemokine 9 (CXCL9), also known as Monokine induced by Interferon-Gamma (MIG) and small inducible cytokine B9. Synthesis of CXCL9 is induced by IFN-gamma and it mediates lymphoytic infiltration to focal sites and inhibits tumor growth. CXCL9 is not detectable under physiological conditions in non-lymphoid tissues. However in response to inflammation or injury, IFN-gamma induces CXCL9 production in blood and tissue cells. CXCL9 is a ligand of CXCR3, a classic 7 transmembrane G protein coupled receptor. Upon binding to this receptor the signaling pathways Src, PI3k and MAPK can be activated. The purified Mouse anti Human CXCL9 antibody, clone C04-3E4 (MCA6252GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CXCL9 antibody, clone C09-9H7 (MCA6253B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CXCL9 (Thr23-Thr125).

Mouse

Monoclonal

C04-3E4

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CXCL9 antibody, clone C04-3E4, recognizes, C-X-C motif chemokine 9 (CXCL9), also known as Monokine induced by Interferon-Gamma (MIG) and small inducible cytokine B9. Synthesis of CXCL9 is induced by IFN-gamma and it mediates lymphoytic infiltration to focal sites and inhibits tumor growth (Tokunaga et al. 2018). CXCL9 is not detectable under physiological conditions in non-lymphoid tissues. However in response to inflammation or injury, IFN-gamma induces CXCL9 production in blood and tissue cells. CXCL9 is a ligand of CXCR3, a classic 7 transmembrane G protein coupled receptor. Upon binding to this receptor the signaling pathways Src, PI3k and MAPK can be activated (Koper et al. 2018).The purified Mouse anti Human CXCL9 antibody, clone C04-3E4 (MCA6252GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CXCL9 antibody, clone C09-9H7 (MCA6253B) as the detection antibody.

C-X-C motif chemokine 9, CMK, Gamma-interferon-induced monokine, HuMIG, MIG, Monokine induced by interferon-gamma, SCYB9, Small-inducible cytokine B9