Anti-Daxx Antibody (A283117)

Anti-Daxx Antibody

Rabbit polyclonal antibody to Daxx.

This antibody recognises human Death Domain-Associated Protein 6, a novel Fas binding protein that has been designated DAXX.DAXX binds specifically to the death domain of Fas and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway.DAXX is predominantly a nuclear protein, where it acts as a repressor of EtsI and Pax3 transactivation. When in association with ASK1 kinase DAXX translocates from the nucleus to the cytoplasm.

WB, IHC-P, ELISA

ELISA: 1:7,000 - 1:45,000, IHC-P: 2.5 µg/ml, WB: 1:200 - 1:1,000

Human, Rat, Mouse

Synthetic peptide corresponding to amino acids 261-274 of human DAXX protein.

GTRYPEVNRRIERL

Rabbit

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human DAXX antibody recognises human Death Domain-Associated Protein 6, a novel Fas binding protein that has been designated DAXX. DAXX binds specifically to the death domain of Fas and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. DAXX is predominantly a nuclear protein, where it acts as a repressor of EtsI and Pax3 transactivation. When in association with ASK1 kinase DAXX translocates from the nucleus to the cytoplasm.

BING2, DAP6, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein, hDaxx