Anti-Dectin-1 Antibody [2A11] (FITC) (A279164)

Anti-Dectin-1 Antibody [2A11] (FITC)

Rat monoclonal [2A11] antibody to Dectin-1 (FITC).

This antibody recognises mouse beta-glucan receptor, also known as Dectin-1 or CD369. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells.As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk. Rat anti Mouse Dectin-1 antibody, clone 2A11 inhibits the binding of zymosan to macrophages via the beta-glucan receptor.

Flow Cytometry: Neat for 0.1 mg, 25 µg, 1:5 for 0.5 mg - 1:10 for 0.1 mg, 25 µg, 1:50 for 0.5 mg, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Mouse

Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.

Rat

Monoclonal

2A11

IgG2b

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Rat anti Mouse Dectin-1 antibody, clone 2A11 recognizes murine beta-glucan receptor, also known as Dectin-1 or CD369. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells.As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk. Rat anti Mouse Dectin-1 antibody, clone 2A11 inhibits the binding of zymosan to macrophages via the beta-glucan receptor.

Beta-glucan receptor, BGR, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, CD369, CLEC7A, CLECSF12, DC-associated C-type lectin 1, DECTIN1, Dendritic cell-associated C-type lectin 1

This product is for research use only. It is not intended for diagnostic or therapeutic use.