Anti-DOPA Decarboxylase / DDC Antibody (A283143)

Anti-DOPA Decarboxylase / DDC Antibody

Rabbit polyclonal antibody to DOPA Decarboxylase / DDC.

This antibody recognises DOPA decarboxylase, also known as aromatic-L-amino acid decarboxylase or DDC), an enzyme that catalyses the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. The enzyme is expressed ubiquitously and is essential for the formation of catecholamines, indoleamines and trace amines. DDC is considered to be the rate-limiting step for the formation of trace amines, but not for the formation of catecholamines or indoleamines. It also becomes rate-limiting for dopamine formation in Parkinson's disease patients treated with L-DOPA.

WB: 1:1,000

Bovine, Rat

SDS denatured, recombinant bovine DOPA decarboxylase expressed E. coli and purified from inclusion bodies.

Rabbit

Polyclonal

IgG

Approximately 55 kDa in rat adrenal medulla.

Liquid

Supplied in 10mM HEPES, pH 7.5, with 150mM NaCl, 0.01% BSA, 50% Glycerol, and 0.05% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Bovine DOPA decarboxylase antibody recognizes DOPA decarboxylase, also known as aromatic-L-amino acid decarboxylase or DDC), an enzyme that catalyses the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. The enzyme is expressed ubiquitously and is essential for the formation of catecholamines, indoleamines and trace amines. DDC is considered to be the rate-limiting step for the formation of trace amines, but not for the formation of catecholamines or indoleamines. It also becomes rate-limiting for dopamine formation in Parkinson's disease patients treated with L-DOPA.