Anti-Dopamine beta Hydroxylase Antibody [DBH/7224] - BSA and Azide free (A316278)

Anti-Dopamine beta Hydroxylase Antibody [DBH/7224] - BSA and Azide free

Mouse monoclonal [DBH/7224] antibody to Dopamine beta Hydroxylase.

Dopamine -hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer, which is found in the lumen of synaptic vesicles of corresponding nerve cells, where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and Insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A, cyclic AMP, diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1, CREB and AP-1 proteins including c-Fos, c-Jun and JunD.

Human adrenal gland or adrenal pheochromocytoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 200-400) of human DBH protein. The exact sequence is proprietary.

Mouse

Monoclonal

IgG2

kappa

Protein A/G chromatography.

1 mg/ml

78 kDa / 84 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DBH, Dopamine beta-hydroxylase, Dopamine beta-monooxygenase