Anti-DPF2 / REQ Antibody (A320093)

Anti-DPF2 / REQ Antibody

Goat polyclonal antibody to DPF2 / REQ.

This antibody recognises zinc finger protein ubi-d4, also known as BAF45D, REQ, and UBID4.DPF2 is a plant homeodomain (PHD) finger protein with roles in apoptosis, noncanonical NF-kappaB signaling and oncogenesis. It acts as an adaptor protein, linking RelB/p52 with the SWI/SNF chromatin-remodeling complex. In human tissues, DPF2 is ubiquitously expressed but was discovered as being required for apoptosis in myeloid cells. Furthermore, this protein appears to play a role in inhibiting the differentiation of myeloid cells. DPF2 is associated with multiple human cancers including cervical cancer and acute myelogenous leukemia (AML). DPF2 also appears to play a role in influenza infection, with knockdown of DPF2 leading to decreased infectivity of the virus.

WB, IHC-P

IHC-P: 5 µg/ml, WB: 1 µg/ml - 3 µg/ml

Human

A peptide sequence of C-QPPTPVSQRSEEQKS from the internal region of the protein sequence according to NP_006259.1.

C-QPPTPVSQRSEEQKS

Goat

Polyclonal

IgG

500 µg/ml

Approximately 50 kDa and 48 kDa in cell lysates

Liquid

Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Goat anti DPF2 antibody recognizes zinc finger protein ubi-d4, also known as BAF45D, REQ, and UBID4.DPF2 is a plant homeodomain (PHD) finger protein with roles in apoptosis, noncanonical NF-kappaB signaling and oncogenesis (Liu et al. 2015). It acts as an adaptor protein, linking RelB/p52 with the SWI/SNF chromatin-remodeling complex (Shin et al. 2017). In human tissues, DPF2 is ubiquitously expressed but was discovered as being required for apoptosis in myeloid cells. Furthermore, this protein appears to play a role in inhibiting the differentiation of myeloid cells. DPF2 is associated with multiple human cancers including cervical cancer and acute myelogenous leukemia (AML) (Huber et al. 2017). DPF2 also appears to play a role in influenza infection, with knockdown of DPF2 leading to decreased infectivity of the virus (Shin et al. 2017).