Anti-Dynorphin A Antibody (A283838)

Anti-Dynorphin A Antibody

Rabbit polyclonal antibody to Dynorphin A.

This antibody recognises the opioid peptide dynorphin A , a cleavage product of big dynorphin, itself derived from the precursor pro-encephalin-B, also known as preprodynorphin. Rabbit anti dynorphin A antibody binds to both dynorphin A 1-17 and 1-8 but not with other big dynorphin cleavage products such as dynorphin B, also known as rimorphin. Dynorphin A immunoreactive cells are found in the paraventricular and supraoptic nucleus and in hippocampal mossy fibers of rat brain following kainic acid administration and colchicine induced neurotoxicity. Dynorphins play a role in multiple physiologic processes including pain perception and responses to stress (Rácz et al. 2013). They mimic and compete with a number of opiate drugs(Chavkin 2013). Dysregulation of dynorphin A expression has been linked to progression of neurodegenerative conditions such as Altzheimer’s disease and appears to play a significant role in the pathobiology of epilepsy. Rabbit anti dynorphin antibody has been used successfully for the immunohistochemical demonstration of ‘mossy fibre’ sprouting in hippocampal sclerosis and in a virally induced disease model in the rat.

IHC-P, IHC-Fr, RIA

IHC-Fr: 1:100 - 1:1500, RadioIAs: 1:10,000

Porcine, Rat, Rhesus Monkey, Human

Porcine Dynorphin A, amino acids 1-17: YGGFLRRIRPKLKWDNQ.

YGGFLRRIRPKLKWDNQ

Rabbit

Polyclonal

IgG

Diluted Serum.

Liquid

Supplied as diluted serum in Phosphate Buffered Saline with 0.1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti dynorphin A antibody recognizes the opioid peptide dynorphin A (Fischli et al. 1982), a cleavage product of big dynorphin, itself derived from the precursor pro-encephalin-B, also known as preprodynorphin. Rabbit anti dynorphin A antibody binds to both dynorphin A 1-17 and 1-8 but not with other big dynorphin cleavage products such as dynorphin B, also known as rimorphin. Dynorphin A immunoreactive cells are found in the paraventricular and supraoptic nucleus and in hippocampal mossy fibers of rat brain following kainic acid administration and colchicine induced neurotoxicity (McGinty et al. 1983). Dynorphins play a role in multiple physiologic processes including pain perception (Wang et al. 2001)and responses to stress (Rácz et al. 2013). They mimic and compete with a number of opiate drugs(Chavkin 2013). Dysregulation of dynorphin A expression has been linked to progression of neurodegenerative conditions such as Altzheimer’s disease (Yakovleva et al. 2007) and appears to play a significant role in the pathobiology of epilepsy (Loacker et al. 2007). Rabbit anti dynorphin antibody has been used successfully for the immunohistochemical demonstration of ‘mossy fibre’ sprouting in hippocampal sclerosis (Thom et al. 2009) and in a virally induced disease model in the rat (Solbrig et al. 2006).