Anti-EDA2R / XEDAR Antibody (A283053)

Anti-EDA2R / XEDAR Antibody

Rabbit polyclonal antibody to EDA2R / XEDAR.

This antibody recognises human X-linked ectodermal dysplasia receptor (XEDAR), a ~33 kDa type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform of ectodysplasin termed EDA-A2. Binding of ectodysplasin to XEDAR results in the induction of apoptosis, and is thought to be involved ectodermal organ development. XEDAR may also be involved in skeletal muscle development.Two predominant isoforms of XEDAR exist; XEDAR-s and XEDAR-L, produced by alternative splicing.

WB: 0.5 - 2 µg/ml

Human

Recombinant human XEDAR.

Rabbit

Polyclonal

IgG

Approximately 33 kDa in 293 cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human XEDAR antibody detects human X-linked ectodermal dysplasia receptor (XEDAR), a ~33 kDa type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform of ectodysplasin termed EDA-A2. Binding of ectodysplasin to XEDAR results in the induction of apoptosis, and is thought to be involved ectodermal organ development. XEDAR may also be involved in skeletal muscle development.Two predominant isoforms of XEDAR exist; XEDAR-s and XEDAR-L, produced by alternative splicing.