Specificity
Rabbit anti Human epidermal growth factor receptor antibody recognizes human epidermal growth factor receptor (EGFR), also known as Proto-oncogene c-ErbB-1. EGFR is a 1210 amino acid single pass type 1 ~170 kDa transmembrane glycoprotein which is a member of the ErbB family of receptor tyrosine kinases. EGFR is the cell surface receptor for members of the EGF family, and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin, liver and gut (Nautiyal et al. 2010).Mutations to EGFR have been found in many human carcinomas including breast, brain, lung, and colon(Garcia de Palazzo et al. 1993).
