This antibody recognises ETS-related transcription factor Elf-1, also known as E74-like factor 1 (ELF1).ELF1 is a small zinc-finger protein conserved in eukaryotes and some archaea. ELF1 is ubiquitously expressed in human cells and is a member of the ETS family of transcription factors and appears to act downstream of the DNA damage response pathway. In cancer, ELF1 appears to have oncogenic and tumor suppressive functions depending on context. ELF1 appears to play an antiviral role, with lower levels of ELF1 reducing host defense against the influenza A virus.
Applications
WB, IHC-P
Dilutions
IHC-P: 2.5 µg/ml, WB: 0.03 µg/ml - 0.1 µg/ml
Reactivity
Human, Mouse
Immunogen
A peptide sequence of C-AMKQNELLEPNSF from the C-terminus of the protein sequence according to NP_758961.1; NP_001138825.1.
Sequence
C-AMKQNELLEPNSF
Host
Goat
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
500 µg/ml
Molecular Weight
Approximately 70 kDa in cell lysates
Product Form
Liquid
Formulation
Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.
Storage
Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Goat anti ELF1 antibody recognizes ETS-related transcription factor Elf-1, also known as E74-like factor 1 (ELF1).ELF1 is a small zinc-finger protein conserved in eukaryotes and some archaea (Ehara and Sekine 2018). ELF1 is ubiquitously expressed in human cells and is a member of the ETS family of transcription factors (Budka et al. 2018) and appears to act downstream of the DNA damage response pathway (Cheng et al. 2020). In cancer, ELF1 appears to have oncogenic and tumor suppressive functions depending on context (Budka et al. 2018). ELF1 appears to play an antiviral role, with lower levels of ELF1 reducing host defense against the influenza A virus (Seifert et al. 2019).
