Anti-ELK1 Antibody (A320110)

Anti-ELK1 Antibody

Rabbit polyclonal antibody to ELK1.

This antibody recognises ETS domain-containing protein ELK-1.ELK-1 is a protein that functions as a transcription activator. ELK-1 is a member of a subclass of the ETS family known as ternary complex factors (TCFs). TCFs are characterized by a common protein domain that regulates DNA binding to target sequences. In non-neuronal cells, ELK-1 is expressed in the nucleus. However, in mature neurons ELK-1 is present in the cytoplasm as well as the nucleus and plays a crucial role in a number of neurological processes, including the formation of long-term memory and drug addiction. ELK-1 expression has been implicated in a number of diseases, including Down syndrome, Alzheimer’s disease and depression.

IP, WB

IP: 10 µl per IP, WB: 1:500 - 1:1,000

Human

A peptide derived from within the C-terminus of human ELK-1.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti human ELK-1 antibody recognizes ETS domain-containing protein ELK-1.ELK-1is aproteinthat functions as atranscription activator. ELK-1 is a member of a subclass of theETS family known as ternary complex factors (TCFs). TCFs are characterized by a commonprotein domainthat regulatesDNAbinding to target sequences (Zinck et al. 1993). In non-neuronal cells, ELK-1 is expressed in the nucleus. However, in mature neurons ELK-1 is present in the cytoplasm as well as the nucleus and plays a crucial role in a number of neurological processes, includingthe formation of long-term memoryand drug addiction. ELK-1 expression has been implicated in a number of diseases, including Down syndrome,Alzheimer’s disease anddepression (Besnard et al. 2011).

ETS domain-containing protein Elk-1