Anti-Endo G Antibody (A283913)

Anti-Endo G Antibody

Rabbit polyclonal antibody to Endo G.

This antibody recognises human endonuclease G, also known as endoG. Endo G is a 297 amino acid, including a 48 amino acid transit peptide ~36 kDa mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis.EndoG is reported to act independently of caspases and may represent a caspase independent apoptotic pathway initiated from the mitochondria.

WB, IHC-P

IHC-P 1: 15 µg/ml, WB: 1 µg/ml - 2 µg/ml

Human, Rat, Mouse

Synthetic peptide sequence GGPRGPGELAKYGLP corresponding to amino acids 55 - 70 of endonuclease G.

GGPRGPGELAKYGLP

Rabbit

Polyclonal

IgG

Approximately 35 kDa in HepG2 and 3T3 cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Endonuclease G antibody recognizes human endonuclease G, also known as endoG. Endo G is a 297 amino acid, including a 48 amino acid transit peptide ~36 kDa mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis.EndoG is reported to act independently of caspases and may represent a caspase independent apoptotic pathway initiated from the mitochondria (Li et al. 2001).

ENDOG, Endonuclease G, mitochondrial