Anti-FES Antibody [AB04-4F6] (A320293)

Anti-FES Antibody [AB04-4F6]

Mouse monoclonal [AB04-4F6] antibody to FES.

This antibody recognises tyrosine-protein kinase FES/FPS, otherwise known as feline sarcoma/fujinami avian sarcoma oncogene homolog, proto-oncogene c-FES, proto-oncogene c-FPS or p93c-FES.FES is one of two members of a unique family of cytoplasmic protein tyrosine kinases, alongside tyrosine-protein kinase FER. This family of kinases contains a central src homology-2 (SH2) domain and a COOH-terminal tyrosine kinase catalytic domain and are distinct from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of NH2-terminal FER/CIP4 homology and coiled-coil domains. Studies initially suggested that mutations in FES contribute to the development of some cancers. However, more recent research has shown that FES may act a tumor suppressor in colorectal cancer.

WB: 1:1,000

Human

E. coli derived recombinant protein corresponding to amino acids 1-459 of human FES.

MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQL

Mouse

Monoclonal

AB04-4F6

IgG1

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

94 kDa in THP-1 cell lysate

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti human FES antibody, clone AB04-4F6 recognizes tyrosine-protein kinase FES/FPS, otherwise known as feline sarcoma/fujinami avian sarcoma oncogene homolog, proto-oncogene c-FES, proto-oncogene c-FPS or p93c-FES.FES is one of two members of a unique family of cytoplasmic protein tyrosine kinases, alongside tyrosine-protein kinase FER. This family of kinases contains a central src homology-2 (SH2) domain and a COOH-terminal tyrosine kinase catalytic domain and are distinct from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of NH2-terminal FER/CIP4 homology and coiled-coil domains (Sangrar et al. 2005). Studies initially suggested that mutations in FES contribute to the development of some cancers (Ley et al. 2003). However, more recent research has shown that FES may act a tumor suppressor in colorectal cancer (Delfino et al. 2006).

Feline sarcoma/Fujinami avian sarcoma oncogene homolog, FPS, p93c-fes, Proto-oncogene c-Fes, Proto-oncogene c-Fps, Tyrosine-protein kinase Fes/Fps