This antibody recognises Forkhead box protein P2, also known as FOXP2, CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein. FOXP2 is a 715 amino acid ~80 kDa nuclear transcriptional repressor with a role in brain and lung development.Mutations in the FOXP2 gene has been identified Speech-language disorder 1 (SPCH1), a disorder characterized by severe orofacial dyspraxia with speech impairment. Multiple potential isoforms of FOXP2 generated by alternative splicing have been described. Goat anti Human FOXP2 antibody (AHP2020) is expected to recognize the canonical isoform 1 and also isoforms 3 and 9. However the antibody is not expected other isoforms which lack the C-terminal region (UniProt : 015409).
Applications
WB, ELISA
Dilutions
ELISA: 1:32,000, WB: 0.5 - 1.5 µg/ml
Reactivity
Human, Mammals
Immunogen
A peptide sequence of C-REIEEEPLSEDLE from the C-terminus of FOXP2.
Sequence
C-REIEEEPLSEDLE
Host
Goat
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
500 µg/ml
Molecular Weight
Approximately 80 kDa in human cerebellum cell lysates.
Product Form
Liquid
Formulation
Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Goat anti Human FOXP2 antibody recognizes Forkhead box protein P2, also known as FOXP2, CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein. FOXP2 is a 715 amino acid ~80 kDa nuclear transcriptional repressor with a role in brain and lung development.Mutations in the FOXP2 gene has been identified Speech-language disorder 1 (SPCH1), a disorder characterized by severe orofacial dyspraxia with speech impairment (Lai et al. 2001).Multiple potential isoforms of FOXP2 generated by alternative splicing have been described. Goat anti Human FOXP2 antibody (AHP2020) is expected to recognize the canonical isoform 1 and also isoforms 3 and 9. However the antibody is not expected other isoforms which lack the c-terminal region (UniProt : 015409).
Synonyms
CAG repeat protein 44, CAGH44, Forkhead box protein P2, TNRC10, Trinucleotide repeat-containing gene 10 protein
