This antibody recognises GRB2-associated-binding protein 1, also known as GAB1, GRB2-associated binder 1 or Growth factor receptor bound protein 2-associated protein 1 when phosphorylated at tyrosine 627.GAB1 is a docking protein capable of interactions with several different proteins particularly the activation of receptor tyrosine kinase signaling. Phosphorylation of GAB1 at tyrosine 627 leads to SHP2 recruitment and subsequent activation of MAPK signaling.
Applications
WB
Dilutions
WB: 1:1,000
Reactivity
Human
Immunogen
E. coli derived recombinant protein corresponding to amino acids 243-694 of human GAB1.
Protein G affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Molecular Weight
Approximately 102 kDa in HepG2 cell lysates.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti human GAB1 antibody, clone F01/9A4-2 recognizes GRB2-associated-binding protein 1, also known as GAB1, GRB2-associated binder 1 or Growth factor receptor bound protein 2-associated protein 1 when phosphorylated at tyrosine 627.GAB1 is a docking protein capable of interactions with several different proteins particularly the activation of receptor tyrosine kinase signaling. Phosphorylation of GAB1 at tyrosine 627 leads to SHP2 recruitment and subsequent activation of MAPK signaling.
Synonyms
GRB2-associated binder 1, GRB2-associated-binding protein 1, Growth factor receptor bound protein 2-associated protein 1
![Western Blot - Anti-GAB1 Antibody [ARC52035] (A329382) - Antibodies.com](https://cdn.antibodies.com/image/catalog/329/A329382_1.jpg?profile=product_alternative)