This antibody recognises guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, otherwise known as transducin beta chain 1.GNB1 forms heterotrimeric complexes with G protein subunits a and ?. Mutations in the gene encoding GNB1 result in GNB1 syndrome; with symptoms including developmental delay, hypotonia and epilepsy (Steinrücke et al. 2016). The targeting of GNB1 with microRNA miR-545-3P has been shown to inhibit the progression of some cancers including colon cancer and retinoblastoma (Hu et al. 2022; Tang et al. 2022). Mouse anti Human GNB1 antibody detects a band of 33 kDa.
Applications
WB
Dilutions
WB: 1:10,000
Reactivity
Human, Mouse, Rat
Immunogen
E. coli derived recombinant protein corresponding to amino acids 1-340 of human GNB1.
Protein G affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti Human GNB1 antibody recognizes guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, otherwise known as transducin beta chain 1.GNB1 forms heterotrimeric complexes with G protein subunits a and ?. Mutations in the gene encoding GNB1 result in GNB1 syndrome; with symptoms including developmental delay, hypotonia and epilepsy (Steinrücke et al. 2016). The targeting of GNB1 with microRNA miR-545-3P has been shown to inhibit the progression of some cancers including colon cancer and retinoblastoma (Hu et al. 2022; Tang et al. 2022).Mouse anti Human GNB1 antibody detects a band of 33 kDa.
Synonyms
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Transducin beta chain 1
