Anti-Histone H2A.J Antibody (A320116)

Anti-Histone H2A.J Antibody

Rabbit polyclonal antibody to Histone H2A.J.

This antibody recognises Histone H2A.J.Histone H2A.J is a 16 kDa variant of the H2A histone. Histones are nuclear proteins that regulate the nucleosome structure of the chromosomal fibres in eukaryotic cells. Nucleosomes are the smallest subunit of chromatin and are made up of 146 bp of DNA wrapped around an octamer comprised of pairs of the four core histones (H2A, H2B, H3, and H4) (Smith, 1991). Histone H2A.J may be linked to senescence and upregulation of the expression of inflammatory genes. Histone H2A.J may therefore play a role in chronic inflammation and age-related diseases.

WB: 1:1,000, WB: 1:500 - 1:2500

Human, Mouse

A peptide corresponding to amino acids 122-129 of human histone H2A.J.

ESQKTKSK

Rabbit

Polyclonal

IgG

Lot Specific

Liquid

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human histone H2A.J antibody recognizes histone H2A.J.Histone H2A.Jis a16 kDa variant of the H2A histone. Histones are nuclear proteins that regulate the nucleosome structure of the chromosomal fibres in eukaryotic cells. Nucleosomes are the smallest subunit of chromatin and are made up of 146 bp of DNA wrapped around an octamer comprised of pairs of the four core histones (H2A, H2B, H3, and H4) (Smith, 1991). Histone H2A.J may be linked to senescence and upregulation of the expression of inflammatory genes. Histone H2A.J may therefore play a role in chronic inflammation and age-related diseases (Takana et al. 2020).