Anti-HLA DP + DQ + DR Antibody [HLA-Pan/6663] (A277868)

Anti-HLA DP + DQ + DR Antibody [HLA-Pan/6663]

Mouse monoclonal [HLA-Pan/6663] antibody to HLA DP + DQ + DR.

This antibody recognizes a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response.

Flow Cytometry, IHC-P

Flow Cytometry: 1-2 µg/million cells, IHC-P: 1-2 µg/ml

Human

Priess human B cell line.

Mouse

Monoclonal

HLA-Pan/6663

IgG1

Protein A/G chromatography.

200 µg/ml

33-35 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-HLA DP + DQ + DR Antibody [HLA-Pan/6663] - BSA and Azide free (A278456).