This antibody recognises high mobility group nucleosome-binding domain-containing protein 2, also known as non-histone chromosomal protein HMG-17.HMGN2 is a 9 kDa member of the HMG class of chromosomal proteins, the most abundant non-histones present in the nuclei of eukaryotic cells. Chromatin regions with high levels of HMGN2 are enriched in transcriptionally active genes and in acetylated histones. HMGN2 associates with actively transcribed genes. HMGN2 also binds to the inner side of the nucleosomal DNA, thereby regulating the interaction between the DNA and the nucleosome. HMGN2 may also play a role in maintaining transcribable genes in a unique chromatin conformation.
Applications
WB
Dilutions
WB: 1:500 - 1:2,000
Reactivity
Human
Immunogen
A peptide derived from within the N-terminus of human HMGN2.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human HMGN2 antibody recognizes high mobility group nucleosome-binding domain-containing protein 2,also known as non-histone chromosomal protein HMG-17.HMGN2 is a9 kDa member of the HMG class of chromosomal proteins, the most abundant non-histones present in the nuclei of eukaryotic cells (Hock et al. 2007). Chromatin regions with high levels of HMGN2 are enriched in transcriptionally active genes and in acetylated histones. HMGN2 associates with actively transcribed genes. HMGN2 also binds to the inner side of the nucleosomal DNA, thereby regulating the interaction between the DNA and the nucleosome. HMGN2 may also play a role in maintaining transcribable genes in a unique chromatin conformation (Garza-Manero et al. 2019).
Synonyms
High mobility group nucleosome-binding domain-containing protein 2, HMG17, Non-histone chromosomal protein HMG-17
