Recombinant Anti-Human IgA Heavy Chain Antibody [rHISA43] (A248938)

Anti-Human IgA Heavy Chain Antibody [rHISA43]

Recombinant mouse monoclonal [rHISA43] antibody to Human IgA Heavy Chain.

This antibody is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkins lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human IGHA1 and IGHA2 proteins.

Mouse

Monoclonal

rHISA43

IgG1

Protein A/G chromatography.

200 µg/ml

50-75 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Human IgA Heavy Chain Antibody [rHISA43] - BSA and Azide free (A252118).