Anti-IL-17A/F Antibody [D01-1C2] (A280191)

Anti-IL-17A/F Antibody [D01-1C2]

Mouse monoclonal [D01-1C2] antibody to IL-17A/F.

This antibody recognises interleukin-17 A and F. The IL-17 family consists of six proteins (IL-17A to IL-17F) which function as proinflammatory cytokines, important for defence against pathogens. Accordingly, IL-17-producing CD4+ T helper cells, also called Th17 cells, play important roles in immune defense. Uncontrolled IL-17 signaling is associated with immunopathology, autoimmune diseases, and cancer, and blocking activity of IL-17 can be beneficial in some clinical settings. This antibody recognises IL-17A, the most studied member of the IL-17 family, and its closest relative IL-17F. These two proteins have similar structure and inflammatory function, but unique functions of IL-17F in the immune system have also been indicated. The purified Mouse anti Human interleukin-17A/F antibody, clone D01-1C2 (MCA6206GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-17A/F antibody, clone I07-5E4 (MCA6207B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length interleukin-17A/F (Gly24-Ala155).

Mouse

Monoclonal

D01-1C2

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human interleukin-17A/F antibody, clone D01-1C2, recognizes interleukin-17 A and F. The IL-17 family consists of six proteins (IL-17A to IL-17F) which function as proinflammatory cytokines, important for defence against pathogens (Gurczynski and Moore, 2017). Accordingly, IL-17-producing CD4+ T helper cells, also called Th17 cells, play important roles in immune defense. Uncontrolled IL-17 signaling is associated with immunopathology, autoimmune diseases, and cancer, and blocking activity of IL-17 can be beneficial in some clinical settings (Amatya et al. 2017). This antibody recognizes IL-17A, the most studied member of the IL-17 family, and its closest relative IL-17F (Chen and Kolls 2017). These two proteins have similar structure and inflammatory function, but unique functions of IL-17F in the immune system have also been indicated (Chang and Dong, 2009). The purified Mouse anti Human interleukin-17A/F antibody, clone D01-1C2 (MCA6206GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-17A/F antibody, clone I07-5E4 (MCA6207B) as the detection antibody.