Anti-IL-18BP Antibody [B01-3E12] (A279722)

Anti-IL-18BP Antibody [B01-3E12]

Mouse monoclonal [B01-3E12] antibody to IL-18BP.

This antibody recognises interleukin-18-binidng protein (IL-18BP), also known as tadekinig-alpha. IL-18BP is a secreted immunoregulatory binding protein which binds to and inhibits the cytokine activity of mature IL-18 with high affinity. IL-18 plays a role in host defense, inflammation, tissue repair, and regeneration (Mühl & Bachmann 2019). IL-18BP is constitutively expressed in the spleen, PBMCs, monocytes and umbilical vein endothelial cells (Mühl & Bachmann 2019, Corbaz et al. 2002). It is detectable in the serum of healthy humans at a 20 fold molar excess compared to IL-18, with subjects showing levels of 2,000 – 4,000 pg/ml of IL-18BP. IL-18BP is upregulated in response to inflammation as part of the inflammation resolution process. Additionally, it can be upregulated during various cancers and IL-18BP levels are also affected by viral infections such as dengue and hepatitis C (Mühl & Bachmann 2019).The purified Mouse anti Human interleukin-18BP antibody, clone B01-3E12 (MCA6244GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-18BP antibody, clone A07-5D2 (MCA6245B) as the detection antibody.

ELISA: 1 µg/ml

Human

NS0 derived recombinant human full length interleukin-18BP (Thr31-Gly194).

Mouse

Monoclonal

B01-3E12

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human interleukin-18BP antibody, clone B01-3E12, recognizes interleukin-18-binidng protein (IL-18BP), also known as tadekinig-alpha. IL-18BP is a secreted immunoregulatory binding protein which binds to and inhibits the cytokine activity of mature IL-18 with high affinity. IL-18 plays a role in host defense, inflammation, tissue repair, and regeneration (Mühl & Bachmann 2019). IL-18BP is constitutively expressed in the spleen, PBMCs, monocytes and umbilical vein endothelial cells (Mühl & Bachmann 2019, Corbaz et al. 2002). It is detectable in the serum of healthy humans at a 20 fold molar excess compared to IL-18, with subjects showing levels of 2,000 – 4,000 pg/ml of IL-18BP (Kaplanski et al. 2018). IL-18BP is upregulated in response to inflammation as part of the inflammation resolution process. Additionally, it can be upregulated during various cancers and IL-18BP levels are also affected by viral infections such as dengue and hepatitis C (Mühl & Bachmann 2019).The purified Mouse anti Human interleukin-18BP antibody, clone B01-3E12 (MCA6244GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-18BP antibody, clone A07-5D2 (MCA6245B) as the detection antibody.

IL18BP, Interleukin-18-binding protein, Tadekinig-alfa