Anti-IL-20R1 Antibody [IL20RA/1752] - BSA and Azide free (A316557)

Anti-IL-20R1 Antibody [IL20RA/1752] - BSA and Azide free

Mouse monoclonal [IL20RA/1752] antibody to IL-20R1.

The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-l. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ra and IL-20Rb. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ra and IL-20Rb all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

Human skin, testis, brain or psoriatic skin.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human IL20RA protein. The exact sequence is proprietary.

Mouse

Monoclonal

IgG2

kappa

Protein A/G chromatography.

1 mg/ml

90-100 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CRF2-8, Cytokine receptor class-II member 8, Cytokine receptor family 2 member 8, IL-20 receptor subunit alpha, IL-20R-alpha, IL-20RA, IL20RA, Interleukin-20 receptor subunit alpha, ZcytoR7